Vitamin C

General Anti-cancer Activities

1.Anti-cancer effects of vitamin C revisited

2.Effects of High Doses of Vitamin C on Cancer Patients in Singapore: Nine Cases

3.Ascorbic acid in the prevention and treatment of cancer

4.High-Dose Intravenous Vitamin C Combined with Cytotoxic Chemotherapy in Patients with Advanced Cancer: A Phase I-II Clinical Trial

5.Intravenous Vitamin C and Cancer: A Systematic Review

6.Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress

Bladder Cancer

1.Vitamin C and E intake and risk of bladder cancer: a meta-analysis of observational studies

2.Vitamin C and K3 Combination Causes Enhanced Anticancer Activity against RT-4 Bladder Cancer Cells

3.Vitamin C and Vitamin E Supplement Use and Bladder Cancer Mortality in a Large Cohort of US Men and Women

Bone Cancer

1.The effect of ascorbic acid on bone cancer cells in vitro

Brain Cancer

1.High Dose Ascorbate Causes Both Genotoxic and Metabolic Stress in Glioma Cells

2.The Effect of Ascorbic Acid over the Etoposide- and Temozolomide-Mediated Cytotoxicity in Glioblastoma Cell Culture: A Molecular Study

3.High-Dose Intravenous Vitamin C Treatment of a Child with Neurofibromatosis Type 1 and Optic Pathway Glioma: A Case Report

4.Superoxide-dependent uptake of vitamin C in human glioma cells

Breast Cancer

1.High Dose IV Vitamin C and Metastatic Breast Cancer: A Case Report

2.Vitamin C supplement intake and postmenopausal breast cancer risk: interaction with dietary vitamin C

3.Vitamin C Effect on Mitoxantrone-Induced Cytotoxicity in Human Breast Cancer Cell Lines


Colorectal Cancer

1.Vitamin C Induces Apoptosis in Human Colon Cancer Cell Line, HCT-8 Via the Modulation of Calcium Influx in Endoplasmic Reticulum and the Dissociation of Bad from 14-3-3β

2.Cytotoxicity of Ascorbic Acid in a Human Colorectal Adenocarcinoma Cell Line (WiDr): In Vitro and In Vivo Studies

3.Anticancer Effect of Ascorbic acid and Saengshik on CT-26 Colon Cancer

4.Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions

Esophageal Cancer

1.Role of the vitamin C in diethylnitrosamine-induced esophageal cancer in Wistar rats


1.Ascorbic Acid Induces Apoptosis in Adult T-cell Leukemia

Liver Cancer

1.Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2 Carcinoma Hepa1‑6 Cell Line

2.Vitamin C enhances anticancer activity in methotrexate treated Hep3B hepatocellular carcinoma cells

3.Effects of ascorbic acid and b-carotene on HepG2 human hepatocellular carcinoma cell line

Lung Cancer

1.High dose intravenous vitamin c treatment in a patient with lung cancer: A case Report

2.High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma

3.Association between vitamin C intake and lung cancer: a dose-response meta-analysis


1.Effect of ascorbic acid and hydrogen peroxide on mouse neuroblastoma cells

2.Sodium Ascorbate induces apoptosis in neuroblastoma cell lines by interfering with iron uptake

Oral Cancer

1.Status of Serum and Salivary Ascorbic Acid in Oral Potentially Malignant Disorders and Oral Cancer

Pancreatic Cancer

1.Treatment of pancreatic cancer with intravenous vitamin C:a case report

2.High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study

3.High dose intravenous vitamin c and metastatic pancreatic cancer: Two cases

Prostate Cancer

1.Weekly ascorbic acid infusion in castration-resistant prostate cancer patients: a single-arm phase II trial

2.Intravenous Vitamin C and Metabolic Correction as Adjuvant Therapy for prostate Cancer: a Case Report

3.Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658Subjects

4.Elimination of Ascorbic Acid After High-Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation

Renal cell Carcinoma

1.Induction of Cell Death in Renal Cell Carcinoma With Combination of D Fraction and Vitamin C

Stomach Cancer

1.Pharmacological Ascorbate Suppresses Growth of Gastric Cancer Cells with GLUT1 Overexpression and Enhances the Efficacy of Oxaliplatin Through Redox Modulation

2.Study of Serum Vitamin-C levels in Carcinoma Stomach

3.Mechanism of Ascorbic Acid-induced Reversion Against Malignant Phenotype in Human Gastric Cancer Cells

4.Effect of physiological concentrations of vitamin C on gastric cancer cells and Helicobacter pylori

5.Ascorbic acid and intestinal metaplasia in the stomach: a prospective, randomized study