General Anti-cancer Activities

1. Apigenin in cancer therapy: anti‑cancer effects and mechanisms of action

2. Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

3. Apigenin Suppresses Cancer Cell Growth through ERB

Breast Cancer

1. P53 and Cyclin B1 Mediate Apoptotic Effects of Apigenin And Rutin In ERα+-BREATE Cancer MCF-7 Cells

2. Apigenin Increases Cisplatin Inhibitory Effects on The Telomerase Activity of Triple Negative Breast Cancer Cells

3. Apigenin Regulates Matrix Metalloproteinase-2/9 and Rho GTPase Family through FAK Signal to Reduce Breast Cancer MCF-7 Cells Metastasis

4. Apigenin inhibits TNFα/IL-1α-induced CCL2release through IKBK-epsilon signaling inMDA-MB-231 human breast cancer cells

5. In Vitro Cytotoxic Activity of Matricaria Chamomilla Root Extract in Human Breast Cancer Cell Line MCF-7

6. Induction of Caspase-dependent Apoptosis by Apigenin by Inhibiting STAT3 Signaling in HER2-overexpressingMDA-MB-453 Breast Cancer Cells

Cervical Cancer

1. Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines

2. Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma

Colorectal Cancer

1. Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells

2. Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells

Lung Cancer

1. Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependentmanner

2. Apigenin induces caspase-dependent apoptosis inhuman lung cancer A549 cells through Bax- andBcl-2-triggered mitochondrial pathway

3. Apigenin Inhibits Expression of Vascular Endothelial Growth Factor and Angiogenesis in Human Lung Cancer Cells: Implication of Chemoprevention of Lung Cancer

Ovarian Cancer

1. Oral Administration of Apigenin Inhibits Metastasis through AKT/P70S6K1 /MMP-9 Pathway in Orthotopic Ovarian Tumor Model

2. Apigenin inhibits proliferation of ovarian cancer A2780 cells through Id1