Lung Cancer

Apigenin

1. Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependentmanner

2. Apigenin induces caspase-dependent apoptosis inhuman lung cancer A549 cells through Bax- andBcl-2-triggered mitochondrial pathway

3. Apigenin Inhibits Expression of Vascular Endothelial Growth Factor and Angiogenesis in Human Lung Cancer Cells: Implication of Chemoprevention of Lung Cancer

Curcumin

In Vitro

1. Curcumin Inhibits Growth of Human NCI-H292 Lung Squamous Cell Carcinoma Cells by Increasing FOXA2 Expression

2. Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway

3. Curcumin induced autophagy anticancer effects on human lung adenocarcinoma cell line A549

4. Curcumin and Lung Cancer: the Role of microRNAs

5. Curcumin inhibits the development of non small cell lung cancer by inhibiting autophagy and apoptosis

6. Exploration of inhibitory mechanisms of curcumin in lung cancer metastasis using a miRNA- transcription factor-target gene network

7. Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction

8. Curcumin sensitizes human lung cancer cells to apoptosis and metastasis synergistically combined with carboplatin

9. Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway

10. Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K/Akt signaling pathway

11. Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1

12. Curcumin Induces Apoptosis of Upper Aerodigestive Tract Cancer Cells by Targeting Multiple Pathways

13. Anti-Lung Cancer Activity of the Curcumin Analog JZ534 In Vitro

14. Potential anti-cancer effect of curcumin in human lung squamous cell carcinoma

15. Curcumin induces the apoptosis of non-small cell lung cancer cells through a calcium signaling pathway

16. Curcumin Blocks Small Cell Lung Cancer Cells Migration, Invasion, Angiogenesis, Cell Cycle and Neoplasia through Janus Kinase-STAT3 Signalling Pathway

17. The role of curcumin in response to BPDE-induced DNA damage in human lung epithelial cells.

18. Curcumin Induces Apoptosis in Human Non-small Cell Lung Cancer NCI-H460 Cells through ER Stress and Caspase Cascade- and Mitochondria-dependent Pathways

In Vivo

1.Curcumin inhibits human non-small cell lung cancer xenografts by targeting STAT3 pathway

2. Identification of curcumin-inhibited extracellular matrix receptors in non–small cell lung cancer A549 cells by RNA sequencing

3. Synergistic effect of fenretinide and curcumin for treatment of non-small cell lung cancer

4. Translating Curcumin to the Clinic for Lung Cancer Prevention: Evaluation of the Preclinical Evidence for Its Utility in Primary, Secondary, and Tertiary Prevention Strategies

5. Curcumin Lowers Erlotinib Resistance in Non-Small Cell Lung Carcinoma Cells With Mutated EGF Receptor

6. Study to Evaluate Molecular Mechanics behind Synergistic Chemo-Preventive Effects of Curcumin and Resveratrol during Lung Carcinogenesis

7. Curcumin: A Novel Stat 3 Pathway Inhibitor for Chemoprevention of Lung Cancer

8. Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer

9. Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of 1-antitrypsin in lung cancer

10. Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy

11. Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer

12. Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1

Honokiol

1. Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity

2. Honokiol Induces Apoptosis, G1Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells

3. Honokiol Decreases Lung Cancer Metastasis through Inhibition of The STAT3Signaling Pathway

4. Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function

5. Honokiol Inhibits Non-Small Cell Lung Cancer Cell Migration by Targeting PGE2-Mediated Activation of b-Catenin Signaling

Isoflavones

1. Radioprotection of Lung Tissue by Soy Isoflavones

2. Soy Food Intake and Risk of Lung Cancer: Evidence From the Shanghai Women’s Health Study and a Meta-Analysis

3. Soy Isoflavones Radiosensitize Lung Cancer While Mitigating Normal Tissue Injury

4. Plasma Isoflavones and the Risk of Lung Cancer in Women: A Nested Case–Control Study in Japan

5. Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies

Luteolin

1. Luteolin Inhibits Tumorigenesis and Induces Apoptosis of Non-Small Cell Lung Cancer Cells via Regulation of MicroRNA-34a-5p

2. Anticancer effect of luteolin is mediated by downregulation of TAM receptor tyrosine kinases, but not interleukin-8,in non-small cell lung cancer cells

3. Luteolin is effective in the non-small cell lung cancer model with L858R/T790MEGF receptor mutation and erlotinib resistance

Lycopene

In Vitro

1. The effect of Lycopene as Immunotherapy and Immuno-modulatory in Lung Cancer, Tumor and Autoimmunity Treatment and Prevention

2. Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines

In Vivo

1. Can Smoke-Exposed Ferrets Be Utilized to Unravel the Mechanisms of Action of Lycopene?

2. Lycopene Supplementation Inhibits Lung Squamous Metaplasia and Induces Apoptosis via Up-Regulating Insulin-like Growth Factor-binding Protein 3 in Cigarette Smoke-exposed Ferrets

Clinical Trial

1. Tomato Lycopene and Lung Cancer Prevention: From Experimental to Human Studies

Panax ginseng

1. Bioactivity-guided isolation of ginsenosides from Korean red ginseng with cytotoxic activity against human lung adenocarcinoma cells

2. Ginsenoside from Panax ginseng Meyer Enhances the Cytotoxic and Apoptotic Effect of Cisplatin in A549 Human Lung Cancer Cells

3. Dammarane-type triterpene ginsenoside-Rg18 inhibits human non-small cell lung cancer A549 cell proliferation via G1 phase arrest

4. Modified Panax ginseng extract regulates autophagy by AMPK signaling in A549 human lung cancer cells

5. The antitumor activity study of ginsenosides and metabolites in lung cancer Cell

6. Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice

Probiotics

1. Role of probiotics in the management of lung cancer and related diseases: An Update

Resveratrol

In Vitro

1. Resveratrol raises in vitro anticancer effects of paclitaxel in NSCLC cell line A549 through CO X-2 expression

2. Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells

3. Resveratrol enhanced anticancer effects of cisplatin on non-small cell lung cancer cell lines by inducing mitochondrial dysfunction and cell apoptosis

4. Resveratrol Enhances Etoposide-Induced Cytotoxicity through Down-Regulating ERK1/2 and AKT-Mediated X-ray Repair Cross-Complement Group 1 (XRCC1) Protein Expression in Human Non-Small-Cell Lung Cancer Cells

5. Anti-Inflammatory and Pro-apoptotic Effects of Curcumin and Resveratrol on the Human Lung Fibroblast Cell Line MRC-5

6. Resveratrol Modulates Expression of ABC Transporters in Non-Small Lung Cancer Cells: Molecular Docking and Gene Expression Studies

7. Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage

8. Resveratrol Alters microRNA Expression Profiles in A549 Human Non-Small Cell Lung Cancer Cells

9. Molecular Mechanisms of Resveratrol Action in Lung Cancer Cells Using Dual Protein and Microarray Analyses

10. Resveratrol enhances ionizing radiation-induced premature senescence in lung cancer cells

11. Resveratrol Enhances Radiosensitivity of Human Non-Small Cell Lung Cancer NCI-H838 Cells Accompanied by Inhibition of Nuclear Factor-Kappa B Activation

12.Resveratrol Induces Growth Inhibition, S-phase Arrest, Apoptosis, and Changes in Biomarker Expression in Several Human Cancer Cell Lines

In Vivo

1. Effects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies

2. Resveratrol in lung cancer- a systematic review

3. Study to Evaluate Molecular Mechanics behind Synergistic Chemo-Preventive Effects of Curcumin and Resveratrol during Lung Carcinogenesis

4. In vitro and in vivo Evaluation of the Antitumor Efficiency of Resveratrol Against Lung Cancer

5. Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[]pyrene

Vitamin C

1. High dose intravenous vitamin c treatment in a patient with lung cancer: A case Report

2. High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma

3. Association between vitamin C intake and lung cancer: a dose-response meta-analysis