Colorectal Cancer


1. Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells

2. Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells


1. In Vitro Antiproliferative Activity of Fresh Pineapple Juices on Ovarian and Colon Cancer Cell Lines

2. The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on coloncarcinogenesis is related to antiproliferative and proapoptotic effects


1. Anticancer effects of fucoxanthin and fucoxanthinol on colorectal cancer cell lines and colorectal cancer tissues

2. Carotenoid Intake and Colorectal Cancer Risk: The Multiethnic Cohort Study

3. Dietary Carotenoids and Risk of Colorectal Cancer in a Pooled Analysis of11 Cohort Studies


5. Antioxidants, Carotenoids, and Risk of Rectal Cancer


1. Curcumin Sensitizes Silymarin to Exert Synergistic Anticancer Activity in Colon Cancer Cells

2. Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU

3. Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway

4. Curcumin mediates oxaliplatin acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway

5. Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer

6. Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures

7. Curcumin Modulates DNA Methylation in Colorectal Cancer Cells

8. Curcumin Enhances the Effect of Chemotherapy against Colorectal Cancer Cells by Inhibition of NF-kB and Src Protein Kinase Signaling Pathways

9. Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells

10. Curcumin Targets FOLFOX-surviving Colon Cancer Cells via Inhibition of EGFRs and IGF-1R

11. Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells

12. Curcumin Modulates the Radiosensitivity of Colorectal Cancer Cells by Suppressing Constitutive and Inducible NF-κB Activity

13. Curcumin Targets FOLFOX-surviving Colon Cancer Cells via Inhibition of EGFRs and IGF-1R

14. Curcumin Inhibits Proliferation of Colorectal Carcinoma by Modulating Akt/mTOR Signaling

15. Elimination of Colon Cancer Stem-Like Cells by the Combination of Curcumin and FLOFOX

In Vivo

1. Expanding the Therapeutic Utility of Curcumin: An Experimental Study on DMH-induced Colorectal Cancer

2. Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/b-Catenin Pathways via miR-130a

3. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelialto-mesenchymal transition in chemoresistant colorectal cancer

4. Curcumin Regulates Colon Cancer by Inhibiting P-Glycoprotein in In-situ Cancerous Colon Perfusion Rat Model

5. Possible therapeutic mechanisms of turmeric against colorectal cancer induced by N-methylnitrosourea in experimental models

6. Effect of curcumin on human colon cancer multidrug resistance in vitro and in vivo

7. Curcumin Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to γ-Radiation by Targeting Nuclear Factor-B-Regulated Gene Products

Clinical trials

1. Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial

2. Phase IIA Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia

3. Colorectal Cancer: Chemopreventive Role of Curcumin and Resveratrol

4. Anti-carcinogenic properties of curcumin on colorectal Cancer

5. Curcumin for chemoprevention of colon cancer

Epigallocatechingallate (EGCG)

1. (-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway

2. Epigallocatechingallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling


1. Honokiol as a Radiosensitizing Agent for Colorectal cancers

2. Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells

3. Honokiol in combination with radiation targets Notch signaling to inhibit colon cancer stem cells

4. Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects

5. Synergistic antitumor effects of liposomal honokiol combined with cisplatin in colon cancer models


1. Soy isoflavone consumption and colorectal cancer risk: a systematic review and meta-analysis

2. Isoflavone and Soy food Intake and Colorectal Cancer Risk: A Case-Control Study in Korea

3. Soy Consumption and Colorectal Cancer Risk in Humans: A Meta-Analysis


1. Combination of oncolytic adenovirus and luteolin exerts synergistic antitumor effects in colorectal cancer cells and a mouse model

2. Modulation of G2/M cell cycle arrest and apoptosis by luteolin in human colon cancer cells and xenografts

3. Luteolin, a Bioflavonoid Inhibits Colorectal Cancer through Modulation of Multiple Signaling Pathways: A Review

4. Cytotoxic Effect of Luteolin on Human Colorectal Cancer Cell Line (HCT-15): Crucial Involvement of Reactive Oxygen Species

5. Luteolin Induces Growth Arrest in Colon Cancer Cells Through Involvement of Wnt/β-Catenin/GSK-3βSignaling

Panax ginseng

1. Ginsenoside-Rp1-induced apolipoprotein A-1 expression in the LoVo human colon cancer cell line

2. Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity

3. Red Ginseng Extract Reduced Metastasis of Colon Cancer Cells In Vitro and In Vivo

4. Compound K, a Metabolite of Ginseng Saponin, Induces Mitochondria Dependent and Caspase-Dependent Apoptosis via the Generation of Reactive Oxygen Species in Human Colon Cancer Cells

5. Potential Role of Ginseng in the Treatment of Colorectal Cancer


1. Probiotics as a preventive strategy for surgical infection in colorectal cancer patients: a systematic review and meta-analysis of randomized trials

2. Intestinal microbiota is altered in patients with colon cancer and modified by probiotic intervention

3. Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis

4. Colon Cancer Prevention through Probiotics: An Overview

5. Probiotics and Intestinal Microbiota: Implications in Colon Cancer Prevention

6. Probiotics in colorectal cancer (CRC) with emphasis on mechanisms of action and current perspectives


1. Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/b-Catenin Signal Pathway

2. Resveratrol Suppresses Colitis and Colon Cancer Associated with Colitis

3. Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways


1. Curcumin Sensitizes Silymarin to Exert Synergistic Anticancer Activity in Colon Cancer Cells

Tinospora cordifolia


Vitamin C

1. Vitamin C Induces Apoptosis in Human Colon Cancer Cell Line, HCT-8 Via the Modulation of Calcium Influx in Endoplasmic Reticulum and the Dissociation of Bad from 14-3-3β

2. Cytotoxicity of Ascorbic Acid in a Human Colorectal Adenocarcinoma Cell Line (WiDr): In Vitro and In Vivo Studies

3. Anticancer Effect of Ascorbic acid and Saengshik on CT-26 Colon Cancer

4. Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions