Honokiol

Brain Cancer

1. Enhancing the anti-glioma therapy of doxorubicin by honokiol with biodegradable self-assembling micelles through multiple evaluations

2. Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas

3. Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells

4. Elimination of Cancer Stem-Like Cells and Potentiation of Temozolomide Sensitivity by Honokiol in Glioblastoma Multiforme Cells

5. Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrion-cytochrome c-caspase protease pathway

6. Honokiol Crosses BBB and BCSFB, and Inhibits BrainTumor Growth in Rat 9L Intracerebral Gliosarcoma Model and Human U251 Xenograft Glioma Model

Breast Cancer

1. Chemopreventive Activity of Honokiol against 7, 12 –Dimethylbenz [a]anthracene-Induced Mammary Cancer in Female Sprague Dawley Rats

2. Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

3. Honokiol sensitizes breast cancer cells to TNF-α induction of apoptosis by inhibiting Nur77 expression

4. Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis

5. Honokiol synergizes chemotherapy drugs in multidrug resistant breast cancer cells via enhanced apoptosis and additional programmed necrotic death

6. Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependentpathway and inhibits breast carcinogenesis

7. Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest

Colorectal Cancer

1. Honokiol as a Radiosensitizing Agent for Colorectal cancers

2. Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells

3. Honokiol in combination with radiation targets Notch signaling to inhibit colon cancer stem cells

4. Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects

5. Synergistic antitumor effects of liposomal honokiol combined with cisplatin in colon cancer models

Liver Cancer

1. Non-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways

2. Combined effect of honokiol and rosiglitazone on cell growth inhibition through enhanced G0/G1 phase arrest in hepatoma cells

3. Growth Inhibitory Activity of Honokiol through Cell-cycle Arrest, Apoptosis and Suppression of Akt/mTOR Signaling in Human Hepatocellular Carcinoma Cells

Lung Cancer

1. Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity

2. Honokiol Induces Apoptosis, G1Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells

3. Honokiol Decreases Lung Cancer Metastasis through Inhibition of The STAT3Signaling Pathway

4. Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function

5. Honokiol Inhibits Non-Small Cell Lung Cancer Cell Migration by Targeting PGE2-Mediated Activation of b-Catenin Signaling

Oral Cancer

1. Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy

2. Antitumor activity of 4-O-Methylhonokiol in human oral cancer cells is mediated via ROS generation, disruption of mitochondrial potential, cell cycle arrest and modulation of Bcl-2/Bax proteins

3. Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction

4. Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1

5. Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wnt/𝛽-Catenin Signaling and Apoptosis Induction

Prostate Cancer

1. C-Mycis a novel target of cell cycle arrest by honokiol in prostate cancer cells/a>

2. Honokiol Activates Reactive Oxygen Species-Mediated Cytoprotective Autophagy in Human Prostate Cancer Cells

3. Honokiol, a constituent of Magnolia species, inhibits adrenergic contraction of human prostate strips and induces stromal cell death

4. Honokiol Inhibits Androgen Receptor Activity in Prostate Cancer Cells

5. Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/ phosphorylation and inhibition of E2F1 transcriptional activity

6. Honokiol, a Natural Plant Product, Inhibits the Bone Metastatic Growth of Human Prostate Cancer Cells

Skin Cancer

1. Honokiol inhibits ultraviolet radiation-induced immunosuppression through inhibition of ultraviolet induced inflammation and DNA hypermethylation in mouse skin

2. Antineoplastic Effects of Honokiol on Melanoma

3. Honokiol Inhibits Melanoma Stem Cells by Targeting Notch Signaling

4. Honokiol induces cytotoxic and cytostatic effects in malignant melanoma cancer cells

5. Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: development of topical formulation

6. Chemopreventive Effects of Honokiol on UVB-induced Skin Cancer Development

Stomach Cancer

1. Honokiol induces cell cycle arrest and apoptosis in human gastric carcinoma MGC-803 cell line

2. Honokiol thwarts gastric tumor growth and peritoneal dissemination by inhibiting Tpl2 in an orthotopic model

3. Calpain/SHP-1 Interaction by Honokiol Dampening Peritoneal Dissemination of Gastric Cancer in nu/nu Mice

4. Honokiol Induces Calpain-Mediated Glucose-RegulatedProtein-94 Cleavage and Apoptosis in Human Gastric Cancer Cells and Reduces Tumor Growth